This report presents a high-level overview of the annealing-based quantum computers manufactured by D-Wave. A survey of hundreds of application problems that have been implemented to run on D-Wave processors is also presented, together with a review of some promising early demonstrations of superior performance from hybrid quantum/classical solvers, compared to purely classical alternatives. The report presents an overview of the new Advantage™ quantum computer and of the hybrid solver service (HSS), which can be used to tackle large-scale optimization problems arising in practice.